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Small Trial Shows Estriol, A Pregnancy Hormone,
Reduces MS Lesion Activity In Women With MS

Summary: In a small-scale, early-phase trial of the hormone estriol, a form of estrogen, women with relapsing-remitting MS showed decreases in MRI-detected brain lesion activity and immune responses during treatment, suggesting that additional study of estriol is called for to determine longer-term efficacy and safety.

  • Women who have MS and are pregnant often experience fewer MS symptoms and relapses, especially during the second and third trimester. Because the hormone estriol is elevated during later stages of pregnancy, and mice given pregnancy levels of estriol were shown to have fewer symptoms of an MS-like disease, the hormone was considered as a candidate for testing against MS.
  • Estriol was well tolerated. Six women with relapsing-remitting MS experienced significant decreases in brain lesion numbers and volume, as well as reductions in levels of immune proteins indicative of inflammation.[More]
     
Nerve Conduction & Research of Dr. Stephen Waxman
by Diane O’Connell, InsideMS
Winner of the prestigious 2002 John Dystel Prize for MS Research unravels basic nerve functions to set the stage for nerve repair. Click here to read the article.
 
CDC provides info about MS and Cancer risk
Dr. Matthew M. Zack of the Division of Chronic Disease and Health Promotion for the Centers for Disease Control and Prevention has provided extensive references from MEDLINE that show studies of the risk of cancer associated with multiple sclerosis since 1966.[More]
 
More on Mammograms
Horizons Newsletter, Sept/Oct 1999
If you're a woman, your risk of breast cancer increases as you age. So simply being an older woman puts you at risk for this disease. The key to surviving breast cancer, however, is to find it early, before it has spread.[More]
 
Accessing Preventive Health Exams
by Lorna Smedman, Managing Editor, Inside MS
Vol. 16, No. 2, Summer 1998
Another doctor, another clinic, more tests, more questions—who needs it? But people with MS are just as susceptible to cancer, heart disease, stroke, and other major diseases as anyone else. Along with routine monitoring of blood pressure and cholesterol, women should have annual pelvic exams, Pap tests, and, starting in midlife, mammograms.[More]

 
 

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